Treatment of burns with grafts of tissue
The use of tissue grafts produced from fetal skin cells quickly allowed to treat severely burned children, according to a study by Swiss doctors published online Thursday by the British medical journal The Lancet.
The eight children were treated to the classic candidate skin autografts of extracting small pieces of healthy skin from one point in the patient’s body to graft in injuries to the skin lining can regenerate. The autograft is applied to deep burns, including third-degree (full thickness of the dermis), which do not allow spontaneous scarring.
The team of Professor Patrick Hohlfeld, University Hospital of Lausanne, is interested in obtaining skin thanks to biotechnologies to improve healing of such burns.
With his colleagues have created a bank of fetal skin cells from a donation of fetal skin 4 cm2. The woman, after the interruption of a pregnancy of 14 weeks, gave his consent to take a sample of the fetus and the team received approval from an ethics committee.
Promising treatment of burns with grafts of tissue from fetal origin
The authors note that several million pieces skin (9x12cm) for therapeutic use can be produced from this unique organ donation.
Doctors placed the grafts, small pieces of skin tissues of fetal origin in small lesions flutes. Skin dressings were added regularly.
Children’s wounds were closed in just over two weeks without having to resort to traditional grafts, according to the authors.
“We have shown that fetal skin is a substitute for biological skin that can be used as inputs of high quality leather in a short time to the flutes, without additional grafting techniques,” says Professor Hohlfeld.
The fetal skin cells could have great therapeutic potential for burns or other injuries, according to this specialist who stressed the “simplicity of application.”
A patent application (submitted by Patrick Hohlfeld and Lee Ann Applegate) concerning this system that is dedicated Neocutis, a firm set up with support from the university hospital in Lausanne.
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